Analyzing the Birth and Propagation of Two Distinct Prions, [PSI+] and [Het-s]y, in Yeast

摘要

De novo formation of two structurally and compositionally distinct yeast prions, [PSI+] and [Het-s]y, is similar starting with formation of a peripheral ring and then internal ring, and then daughters propagate the prions as dots. The ring formation, but not dot propagation, requires an endocytic protein Sla2.